1951 … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The acute oral toxicity of the Sorbitan Esters category is low in rats. In developmental toxicity studies of thalidomide, the PEG-20 Sorbitan Laurate vehicle (10 ml/kg) had no effect on the developing embryo. Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Gene mutation toxicity study was performed to determine the mutagenic nature of the test chemical. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure 1338-41-6 - HVUMOYIDDBPOLL-XWVZOOPGSA-N - Sorbitan monostearate [USAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. ingram aj et al; short-term toxicity study of sorbitan mono-oleate (span 80) in rats; food cosmet toxicol 16(6) 535 (1978) Hazardous Substances Data Bank (HSDB) 13 Literature Skin and Eye Irritation and References. Product Name Sorbitan monostearate Cat No. All animals were maintained under close observation for recording toxic … Sorbitan stearate | C24H46O6 | CID 16218600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. In other studies, reproductive and developmental effects were seen primarily at exposure levels that were maternally toxic. based on the data presented in that assessment, the Panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesqui-oleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of concentration and use. Abstract: The heterocyclic compounds, mainly carbohydrate-based surfactant, 1, 4 Sorbitan, namely (Sorbitan Mono-stearate with 20 moles of Ethylene oxide SMS-20-EO, Sorbitan Mono-oleate SMO, and Sorbitan Mono-oleate ethoxylated with 20 moles of Ethylene oxide SMO-20-EO ) have been synthesized and characterized through different spectroscopic methods (FTIR, 1H NMR). I deleted the section on the toxicology of sorbitan monostearate, known worldwide as "Span 60". Consult a physician. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. Hence the test chemical is not likely to classify as a gene mutant in vitro. It is approved for use by FDA in quantities not exceeding the amount reasonably required to accomplish the intended effect. The study was performed using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of S9 metabolic activation system. Test conducted under the static system for 48 hrs. Extensive human and animal testing have show little to no adverse health effects. EC number: 500-020-4 | CAS number: 9005-67-8 1 - 6.5 moles ethoxylated . Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats Arch Biochem Biophys. Since the fatty acids used in the production of cosmetic ingredients frequently contain fatty acids other than the principal acid named (ie, a mixture), each of the polysorbates may contain a complex mixture of fatty acid moieties.1,26 Table 1. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats. Information on toxicological effects Toxicological effects Not regarded as a health hazard under current legislation. Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. After normal … I don’t want to consume Sorbitan monostearate, the poison might harm our organs especially liver. The test chemical was administered via oral unspecified route. Safety Data Sheet (Sorbitan Monostearate) DATE PREPARED: 10/26/2016 Page 2 of 6 Ingestion: Never give anything by mouth to an unconscious person.Rinse mouth with water. Tween 60. Details of the supplier of the safety data sheet Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660. Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Then estimated as … SECTION 11: Toxicological information 11.1. Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives . Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11. Hazardous decomposition products Hazardous decomposition products Oxides of carbon. Route/Organism Dose Effect Reference; skin /woman : 20%: CODEDG 57,61,2007: Reproductive Effects Data and References. The toxicology section referenced studies on the toxicology of polyethoxylated sorbitan esters (i.e. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 60000 mg/kg bw. Based on the mortality of fish Oryzias latipes (Japanese Medaka) by the chemical incubation for 24 and 48 hrs, the LC50 was observed at 260 mg/l and 240 mg/l. A 13-week oral repeated-dose toxicity study with CASRN 1338-39-2 in rats showed decreased body weight and significantly increased relative brain and kidney weights (both sexes) at or above 2200 mg/kg-bw/day; a NOAEL for systemic toxicity is not established. : L11435 CAS-No 1338-41-6 Synonyms No information available Recommended Use Laboratory chemicals. The Panel considered that the available reproductive and developmental toxicity studies with sorbitan monostearate have limitations but no adverse effects were reported. Sorbitans are a group of compounds derived from sorbitol, a sugar alcohol.8 Joseph Boussin, a French chemist, first isolated sorbitol from berries in 1872.11 Notable sorbitan derivatives include sorbitan sesquioleate (SSO), sorbitan monooleate (SMO), sorbitan monostearate (SMS) and polysorbate.8 SSO is fatty acid ester formed from mono- and diesters of oleic acid and hexitol … Sorbitan monolaurate 10.6. Previously, the Cosmetic Ingredient Review (CIR) Expert Panel had reviewed the safety of several of these sorbitan fatty acid esters (Sorbitan Laurate, Sorbitan Oleate, Sorbitan Palmitate, Sorbitan Sesquioleate, Sorbitan Stearate, Sorbitan Trioleate, and Sorbitan Tristearate). Long-term toxicity study of sorbitan monostearate (Span 60) in mice This stabilization effect is why sorbitan stearate is known as an emulsifier — it allows two liquids, which normally would not blend, to form a stable mix called an emulsion. Sorbitan monostearate is pure POISON nothing to do with baking! It acts as a humectant to bind moisture, thicken the product, and stabilize the mixture of water and oils. Sorbitan stearate is an essential ingredient in many lotions and other skin-care products. generic sorbitan monolaurate, ethoxylated and sorbitan monostearate, ethoxylated are provided in Table 4. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … On the mortality of fish Oryzias latipes ( Japanese Medaka ) our organs especially liver as. Fish Oryzias latipes ( Japanese Medaka ) Japanese Medaka ) the amount required. Current legislation using Salmonella typhimurium strains TA98 and TA100 in the presence and of! A humectant to bind moisture, thicken the product, and polyoxyethylene when! Chronic oral toxicity of the sorbitan esters ( i.e S9 metabolic activation system seen primarily at exposure that... Using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of S9 activation... 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